Line name: Xla.Tg(rho:NTR)Zuber
Synonyms: XOP-NTR, XOPNTR
RRID: EXRC_0049
EXRC line: #49
Non-standard MTA required: No
Transgene description: E. coli nitroreductase (NTR) expressed under the control of the X. laevis rhodopsin promoter (-508/+41) from Barry Knox. Base vector is pEGFP-N1 (Clontech) lacking CMV immediate early promoter
Phenotype: Nitroreductase expression in rod photoreceptors. Addition of Metronidazole results in rapid, specific death of rod cells. Expression pattern is best detected by in situ hybridization for nitroreductase.
Source lab: Zuber lab
Publication: Choi, R., et. al. (2011) “Cone Degeneration Following Rod Ablation in a Reversible Model of Retinal Degeneration.” Invest Ophthalmol Vis Sci 52: 364-373.
Knox, B., et. al. (1998) “Transgene expression in Xenopus rods.” FEBS Lett 423: 117-121
Species: X. laevis
Background strain:
Paternal:
Maternal:
Colour morph:
Available as frozen sperm only
