#49 XOPNTR [Xla.Tg(rho:NTR)Zuber]

Line name: Xla.Tg(rho:NTR)Zuber

Synonyms: XOP-NTR, XOPNTR

RRID: EXRC_0049

EXRC line: #49

Non-standard MTA required: No

Transgene description:  E. coli nitroreductase (NTR) expressed under the control of the X. laevis rhodopsin promoter (-508/+41) from Barry Knox. Base vector is pEGFP-N1 (Clontech) lacking CMV immediate early promoter

Phenotype: Nitroreductase expression in rod photoreceptors. Addition of Metronidazole results in rapid, specific death of rod cells. Expression pattern is best detected by in situ hybridization for nitroreductase.

Source lab: Zuber lab

Publication: Choi, R., et. al. (2011) “Cone Degeneration Following Rod Ablation in a Reversible Model of Retinal Degeneration.” Invest Ophthalmol Vis Sci 52: 364-373.
Knox, B., et. al. (1998) “Transgene expression in Xenopus rods.” FEBS Lett 423: 117-121

Species: X. laevis

Background strain:

Paternal:

Maternal:

Colour morph: