Xtr.myh6mZimml (muzak)

Line name: Xtr.myh6mZimml

Synonyms: T331-C, muzak F4-C


Non-standard MTA required: No

Mutated gene:myosin, heavy chain 6, cardiac muscle, alpha

Phenotype:no heartbeat,

Type of mutation: Chemically-induced (ENU).

Source lab: Zimmerman

Species: X. tropicalis

Publication: Abu-Daya A, Sater AK, Wells DE, Mohun TJ, Zimmerman LB. Absence of heartbeat in the Xenopus tropicalis mutation muzak is caused by a nonsense mutation in cardiac myosin myh6. Dev Biol. 2009;336(1):20-9.

The muz allele encodes a truncated myh6 protein lacking the myosin coiled-coil tail, muz mutants show significantly diminished expression of myh6 mRNA in heart and jaw muscle. Image published in Abu-Daya et al. (2010)