Xtr.tbxttmJcsm Xbra talen mutant

Line name: Xtr.tbxttmJcsm

Synonyms: t, xbra, te1.2D/+ (F2 


Non-standard MTA required: Yes

Mutated gene:T-box transcription factor T

Phenotype: the null mutation abrogates mesodermal cell determination at the very posterior end. Heterozygous line t (Xbra) -/+ does not show any overt phenotype. Homozygous t (Xbra) -/- tailbud shows slightly truncated tail.

Type of mutation: Talen-induced deletion of 2bp in exon 1.

Source lab: Smith lab

Species: X. tropicalis

Publication: Gentsch, G.E., Spruce, T., Monteiro, R.S., Owens, N.D.L., Martin, S.R., and Smith, J.C. (2018). Innate Immune Response and Off-Target Mis-splicing Are Common Morpholino-Induced Side Effects in Xenopus. Dev Cell 44, 597–610.e10.

Xtr.tbxt homozygous mutant embryos (-/-), show a mild tail truncation phenotype. Image published in: Gentsch GE, et al. (2018)